Characterization of myocardial T1 and partition coefficient as a function of time after gadolinium delivery in healthy subjects
نویسندگان
چکیده
Background Diffuse myocardial fibrosis is associated with myocardial infarction [1], heart failure [2] and dilated cardiomyopathy [3]. Conventional T1-weighted late gadolinium enhancement (LGE) imaging highlights focal scaring in contrast to remote reference tissue, but it cannot detect global changes in T1 associated with diffuse fibrosis. Quantitative T1 imaging permits assessment of diffuse fibrosis by eliminating the use of reference tissue, but the dependence of the derived partition coefficient (lambda) on the time post-contrast injection (tpost) is not well established.
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